Next-Generation Retinol Hydroxypinacolone Retinoate (HPR)
Hydroxypinacolone Retinoate (HPR) is a latest-generation retinoid — an ester derivative of retinoic acid that acts directly on the skin's retinoid receptors without the need for metabolic conversion. Unlike classic retinol, which must be converted into retinoic acid (a multi-step process that is taxing for the skin), HPR works immediately, so it does not cause flaking, irritation or sun sensitivity. It stimulates collagen production, accelerates cell renewal, and reduces wrinkles, discolouration and signs of photoaging. It achieves efficacy comparable to retinol with far better tolerance — making it ideal for sensitive, dry skin and for those just starting out with retinoids. It is a breakthrough ingredient in modern anti-age skincare — the effects of younger-looking skin without the cost of "retinisation".
RENEWAL0.2% HPR: efficacy comparable to 0.5% retinol in reducing wrinkles without irritation (in vivo, n=30, Hexacosanoyl Lab 2018).
An ester derivative of retinoic acid — it binds directly to RAR/RXR receptors without metabolic conversion (retinol → retinaldehyde → retinoic acid). It stimulates type I collagen synthesis and epidermal renewal.















